Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned?

Space and the vestibular system: what has been learned?

What has been learned from computational models of attention

There are few fields where neurocomputational modelling 1 is as necessary as in that of attention — a multifaceted and 2 elusive process that is at the very core of cognition and con3 sciousness (James, 1890). While descriptive theories of at4 tentional functions, relying on a plethora of metaphors (spot5 light/zoomlens, increased-gain, biased-competition), abound, 6 computational models that a...

Strategies for quantifying the relationship between medications and suicidal behaviour: what has been learned?

In recent years there has been considerable concern that certain classes of drugs, for example antidepressants, may increase the risk of suicide. In this current opinion article, we examine the literature on methodological and statistical approaches to the design and analysis of suicidal event studies. Experimental, ecological and observational studies of the relationship between drugs and suic...

Centrifugation as a countermeasure during bed rest and dry immersion: What has been learned?

OBJECTIVES We review the studies that have evaluated intermittent short-radius centrifugation as a potential countermeasure for cardiovascular, musculoskeletal, and sensorimotor deconditioning in simulated weightlessness. METHODS The findings from 18 experimental protocols that have used bed rest and dry immersion for comparing the protective effects of centrifugation versus standing upright ...

What has been learned about the cardiovascular effects of matrix metalloproteinases from mouse models?

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for extracellular protein degradation in the cardiovascular system. Originally known to play pivotal roles in tissue morphogenesis and wound healing, they have been shown to participate in the complex remodeling processes in blood vessels and the myocardium. The biological activity of MMPs is regulated at different...